Characteristic | Description |
---|---|
Generic Name | Dapoxetine |
Brand Names | Priligy, Westoxetin |
Dosage Forms | Tablets: 30mg, 60mg |
Indications | Premature Ejaculation |
Mechanism of Action | Selective Serotonin Reuptake Inhibitor |
Learn More About Dapoxetine |
Pharmacokinetics of Dapoxetine
The pharmacokinetic profile of Dapoxetine 30mg is characterized by rapid absorption. Peak plasma concentrations are reached within 1 to 2 hours post-dose. Its bioavailability is moderate, hovering around 42%. This SSRI exhibits a half-life of approximately 18 hours, facilitating a quick onset of action and swift clearance. Hepatic metabolism involves cytochrome P450 enzymes, primarily CYP2D6 and CYP3A4. Consequently, it forms metabolites with negligible activity. Dapoxetine is predominantly excreted via urine.
Concomitant ingestion with food slightly delays absorption but does not affect systemic exposure. Interactions with other drugs, particularly CYP inhibitors, may alter its pharmacokinetic parameters. Adjustments in dosage may become necessary in such instances to maintain efficacy and safety. Caution is advisable when co-administered with other serotonergic agents.
Dapoxetine Use in Treatment
Dapoxetine is primarily indicated for the treatment of premature ejaculation in men aged 18-64 years. This condition often impairs quality of life and interpersonal relationships. The therapeutic action stems from its ability to enhance serotonergic activity in the central nervous system, thus delaying ejaculation.
Administer Dapoxetine 60mg on-demand, one to three hours before anticipated sexual activity. It is not intended for continuous daily use. Maximum recommended frequency is once per 24 hours. Dosage should be individualized based on therapeutic response and tolerability. Initiate therapy at the lower dosage to assess efficacy and side effects.
Warnings and Precautions
Monitor patients for the emergence of side effects or mood changes. Syncope and orthostatic hypotension are potential risks. Alcohol consumption may potentiate these effects, so caution is essential. Evaluate the benefit-risk profile for patients with underlying cardiovascular disorders. Caution in patients with a history of seizures or psychiatric disorders is recommended.
Patients with hepatic impairment should exercise caution. Severe renal impairment also necessitates vigilance. Regular follow-up ensures safety and efficacy of treatment, allowing timely detection of adverse effects.
Managing a Missed Dose
Due to its on-demand nature, missing a dose of Dapoxetine 30mg poses minimal risks. If a dose is missed, patients should not double the next dose. Instead, resume the normal schedule at the next intended time. This approach prevents excessive exposure and potential side effects.
Coping with Dapoxetine Side Effects
Adverse effects associated with Dapoxetine are usually mild and transient. Common issues include nausea, dizziness, and headache. Adequate hydration and rest can mitigate these effects. If severe or persistent, medical consultation is advisable. Patients should report serious reactions, including mood changes or syncope, to healthcare providers.
Adherence to prescribed dosing and precautionary measures minimizes the risk of side effects. Regular follow-up appointments facilitate the identification and management of any adverse reactions.
Availability of Dapoxetine OTC
Dapoxetine is not typically available over-the-counter due to the need for professional medical oversight. Its prescription-only status ensures appropriate use under guidance. This approach reduces risks and optimizes treatment outcomes.
Patients should consult healthcare professionals for proper diagnosis and treatment options. This ensures the therapy aligns with individual health conditions and minimizes potential risks associated with unsupervised use.
Information taken from:
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- https://www.landsdalemotorwreckers.com.au/sickle-cell-disease-a-new-hope-with-promacta/
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- https://www.911mg.org/womens-health/lady-era.htm
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